RodrigoMedeiros.Com

My research focuses on elucidating the processes that result in memory loss and other major neurological deficits, with an emphasis on Alzheimer’s disease (AD) and related neurodegenerative disorders. My long-term goal is to advance the understanding of the healthy and the diseased central nervous system to a point where rational strategies can be developed for the prevention and cure of these conditions.

What I Do

My main research topic is to evaluate the involvement of the inflammatory process in the molecular and behavior changes induced by the β-amyloid (Aβ) protein. My studies demonstrated that Tumor Necrosis Factor-α (TNF-α), inducible Nitric Oxide Synthase (iNOS) and Bradykinin (BK) signaling pathways are linked and exert an important role in the cognitive deficits observed in the earlier stages of AD, suggesting those molecules as possible targets for AD drug discovery.