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Alzheimer's Disease Research
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Figueiredo CP, Antunes VL, Moreira EL, de Mello N, Medeiros R, Di Giunta G, Lobão-Soares
B, Linhares M, Lin K, Mazzuco TL, Prediger RD, Walz R. Glucose-dependent insulinotropic
peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe
epilepsy patients and rats undergoing pilocarpine induced status epilepticus. Peptides.
2010, DOI:10.1016/j.peptides.2010.12.010.
Figueiredo CP, Bicca MA, Latini A, Prediger RD, Medeiros R, Calixto JB. Folic Acid Plus α-
Tocopherol Mitigates Amyloid-β-Induced Neurotoxicity through Modulation of
Mitochondrial Complexes Activity. J Alzheimers Dis. 2010.
Medeiros R, Baglietto-Vargas D, Laferla FM. The Role of Tau in Alzheimer's Disease and
Related Disorders. CNS Neurosci Ther. 2010. DOI: 10.1111/j.1755-5949.2010.00177.x.
Medeiros R, Figueiredo CP, Pandolfo P, Duarte FS, Prediger RD, Passos GF, Calixto JB.The
role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive decline induced
by beta-amyloid peptide. Behav Brain Res. 2010 May 1;209(1):165-73.
Passos GF, Figueiredo CP, Prediger RD, Silva KA, Siqueira JM, Duarte FS, Leal PC, Medeiros
R, Calixto JB. Involvement of phosphoinositide 3-kinase gamma in the neuroinflammatory
response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice. Brain
Behav Immun. 2010 Mar;24(3):493-501.
Passos GF, Figueiredo CP, Prediger RD, Pandolfo P, Duarte FS, Medeiros R, Calixto JB. Role
of the Macrophage Inflammatory Protein-1α/CC Chemokine Receptor 5 Signaling Pathway
in the Neuroinflammatory Response and Cognitive Deficits Induced by β-Amyloid Peptide.
Am J Pathol. 2009 Oct;175(4):1586-97.
Prediger RD, Rial D, Medeiros R, Figueiredo CP, Doty RL, Takahashi RN. Risk is in the air:
an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of
Parkinson's disease. Ann N Y Acad Sci. 2009, 1170:629-36.
Medeiros R, Figueiredo CP, Passos GF, Calixto JB. Reduced skin inflammatory response in
mice lacking inducible nitric oxide synthase. Biochem Pharmacol. 2009, 78(4):390-5.
Marotta DM, Costa R, Motta EM, Fernandes ES, Medeiros R, Quintão NL, Campos MM, Calixto
JB. Mechanisms underlying the nociceptive responses induced by platelet-activating
factor (PAF) in the rat paw. Biochem Pharmacol. 2009, 77(7):1223-35.
Medeiros R, Rodrigues GB, Figueiredo CP, Rodrigues EB, Grumman A Jr, Menezes-de-Lima
O Jr, Passos GF, Calixto JB. Molecular mechanisms of topical anti-inflammatory effects of
lipoxin A(4) in endotoxin-induced uveitis. Mol Pharmacol, 2008, 74:154-61.
Quintão NL, Passos GF, Medeiros R, Paszcuk AF, Motta FL, Pesquero JB, Campos MM, Calixto
JB. Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of
kinin B1 and B2 receptors. J Neurosci, 2008, 28:2856-63.
Prediger RD, Medeiros R, Pandolfo P, Duarte FS, Passos GF, Pesquero JB, Campos MM,
Calixto JB, Takahashi RN. Genetic deletion or antagonism of kinin B(1) and B(2) receptors
improves cognitive deficits in a mouse model of Alzheimer's disease. Neuroscience, 2008,
151:631-43.
Ferreira J, Trichês KM, Medeiros R, Cabrini DA, Mori MA, Pesquero JB, Bader M, Calixto JB.
The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C
activation in mice. Neuropharmacology, 2008, 54:597-604.
Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM, Pianowski LF,
Calixto JB. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-
caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J Pharmacol, 2007,
569:228-36.
Medeiros R, Prediger RD, Passos GF, Pandolfo P, Duarte FS, Franco JL, Dafre AL, Di Giunta G,
Figueiredo CP, Takahashi RN, Campos MM, Calixto JB. Connecting TNF-alpha signaling
pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the
behavioral and synaptic deficits induced by amyloid beta protein. J Neurosci, 2007, 27:
5394-404.
Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB.
Effect of two active compounds obtained from the essential oil of Cordia verbenacea on
the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol, 2007,
151:618-27.
Medeiros R, Otuki MF, Avellar MC, Calixto JB. Mechanisms underlying the inhibitory
actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation
induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Eur J Pharmacol, 2007,
559:227-35.
Fernandes ES, Medeiros R, Campos MM, Calixto JB. PAF-induced kinin B1 receptor in vivo
up-regulation: involvement of distinct kinase pathways. Inflammation Research, 2007, 56:
488-491.
Rodrigues GB, Passos GF, Di Giunta G, Figueiredo CP, Rodrigues EB, Grumman A Jr,
Medeiros R, Calixto JB. Preventive and therapeutic anti-inflammatory effects of systemic
and topical thalidomide on endotoxin-induced uveitis in rats. Exp Eye Res, 2007, 84:553-
60.
Prediger RD, Franco JL, Pandolfo P, Medeiros R, Duarte FS, Di Giunta G, Figueiredo CP,
Farina M, Calixto JB, Takahashi RN, Dafre AL. Differential susceptibility following beta-
amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a
dissociation between cognitive deficits and the glutathione system response. Behav Brain
Res, 2007, 177:205-13.
El Sayah M, Medeiros R, Fernandes ES, Campos MM, Calixto JB. Mechanisms underlying
lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris sphincter in
vitro. Mol Pharmacol, 2006, 69:1701-8.
Prediger RD, Batista L, Medeiros R, Pandolfo P, Florio J, Takahashi R. The risk is in the air:
Intranasal administration of MPTP to rats reproducing clinical features of Parkinson’s
disease. Exp Neurol. 2006, 202:391-403.
Quintão NL, Medeiros R, Santos AR, Campos MM, Calixto JB. The effects of diacerhein on
mechanical allodynia in inflammatory and neuropathic models of nociception in mice.
Anesth Analg, 2005, 101:1763-9.
Ferreira J, Trichês KM, Medeiros R, Calixto JB. Mechanisms involved in the nociception
produced by peripheral protein kinase c activation in mice. Pain, 2005, 117:171-81.
Schlemper V, Medeiros R, Ferreira J, Campos MM, Calixto JB. Mechanisms underlying the
relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in
vitro. Br J Pharmacol, 2005, 145:740-50.
Calixto JB, Medeiros R, Fernandes ES, Ferreira J, Cabrini DA, Campos MM. Kinin B1
receptors: key G-protein-coupled receptors and their role in inflammatory and painful
processes. Br J Pharmacol, 2004, 143:803-18.
Medeiros R, Cabrini DA, Ferreira J, Fernandes ES, Mori MA, Pesquero JB, Bader M, Avellar
MC, Campos MM, Calixto JB. Bradykinin B1 receptor expression induced by tissue damage
in the rat portal vein: a critical role for mitogen-activated protein kinase and nuclear
factor-kappaB signaling pathways. Circ Res. 2004, 94:1375-82.
Medeiros R, Cabrini DA, Calixto JB. The "in vivo" and "ex vivo" roles of cylcooxygenase-2,
nuclear factor-kappaB and protein kinases pathways in the up-regulation of B1 receptor-
mediated contraction of the rabbit aorta. Regul Pept, 2001, 97:121-30.
B, Linhares M, Lin K, Mazzuco TL, Prediger RD, Walz R. Glucose-dependent insulinotropic
peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe
epilepsy patients and rats undergoing pilocarpine induced status epilepticus. Peptides.
2010, DOI:10.1016/j.peptides.2010.12.010.
Figueiredo CP, Bicca MA, Latini A, Prediger RD, Medeiros R, Calixto JB. Folic Acid Plus α-
Tocopherol Mitigates Amyloid-β-Induced Neurotoxicity through Modulation of
Mitochondrial Complexes Activity. J Alzheimers Dis. 2010.
Medeiros R, Baglietto-Vargas D, Laferla FM. The Role of Tau in Alzheimer's Disease and
Related Disorders. CNS Neurosci Ther. 2010. DOI: 10.1111/j.1755-5949.2010.00177.x.
Medeiros R, Figueiredo CP, Pandolfo P, Duarte FS, Prediger RD, Passos GF, Calixto JB.The
role of TNF-alpha signaling pathway on COX-2 upregulation and cognitive decline induced
by beta-amyloid peptide. Behav Brain Res. 2010 May 1;209(1):165-73.
Passos GF, Figueiredo CP, Prediger RD, Silva KA, Siqueira JM, Duarte FS, Leal PC, Medeiros
R, Calixto JB. Involvement of phosphoinositide 3-kinase gamma in the neuroinflammatory
response and cognitive impairments induced by beta-amyloid 1-40 peptide in mice. Brain
Behav Immun. 2010 Mar;24(3):493-501.
Passos GF, Figueiredo CP, Prediger RD, Pandolfo P, Duarte FS, Medeiros R, Calixto JB. Role
of the Macrophage Inflammatory Protein-1α/CC Chemokine Receptor 5 Signaling Pathway
in the Neuroinflammatory Response and Cognitive Deficits Induced by β-Amyloid Peptide.
Am J Pathol. 2009 Oct;175(4):1586-97.
Prediger RD, Rial D, Medeiros R, Figueiredo CP, Doty RL, Takahashi RN. Risk is in the air:
an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of
Parkinson's disease. Ann N Y Acad Sci. 2009, 1170:629-36.
Medeiros R, Figueiredo CP, Passos GF, Calixto JB. Reduced skin inflammatory response in
mice lacking inducible nitric oxide synthase. Biochem Pharmacol. 2009, 78(4):390-5.
Marotta DM, Costa R, Motta EM, Fernandes ES, Medeiros R, Quintão NL, Campos MM, Calixto
JB. Mechanisms underlying the nociceptive responses induced by platelet-activating
factor (PAF) in the rat paw. Biochem Pharmacol. 2009, 77(7):1223-35.
Medeiros R, Rodrigues GB, Figueiredo CP, Rodrigues EB, Grumman A Jr, Menezes-de-Lima
O Jr, Passos GF, Calixto JB. Molecular mechanisms of topical anti-inflammatory effects of
lipoxin A(4) in endotoxin-induced uveitis. Mol Pharmacol, 2008, 74:154-61.
Quintão NL, Passos GF, Medeiros R, Paszcuk AF, Motta FL, Pesquero JB, Campos MM, Calixto
JB. Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of
kinin B1 and B2 receptors. J Neurosci, 2008, 28:2856-63.
Prediger RD, Medeiros R, Pandolfo P, Duarte FS, Passos GF, Pesquero JB, Campos MM,
Calixto JB, Takahashi RN. Genetic deletion or antagonism of kinin B(1) and B(2) receptors
improves cognitive deficits in a mouse model of Alzheimer's disease. Neuroscience, 2008,
151:631-43.
Ferreira J, Trichês KM, Medeiros R, Cabrini DA, Mori MA, Pesquero JB, Bader M, Calixto JB.
The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C
activation in mice. Neuropharmacology, 2008, 54:597-604.
Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM, Pianowski LF,
Calixto JB. Anti-inflammatory effects of compounds alpha-humulene and (-)-trans-
caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J Pharmacol, 2007,
569:228-36.
Medeiros R, Prediger RD, Passos GF, Pandolfo P, Duarte FS, Franco JL, Dafre AL, Di Giunta G,
Figueiredo CP, Takahashi RN, Campos MM, Calixto JB. Connecting TNF-alpha signaling
pathways to iNOS expression in a mouse model of Alzheimer's disease: relevance for the
behavioral and synaptic deficits induced by amyloid beta protein. J Neurosci, 2007, 27:
5394-404.
Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM, Calixto JB.
Effect of two active compounds obtained from the essential oil of Cordia verbenacea on
the acute inflammatory responses elicited by LPS in the rat paw. Br J Pharmacol, 2007,
151:618-27.
Medeiros R, Otuki MF, Avellar MC, Calixto JB. Mechanisms underlying the inhibitory
actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation
induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Eur J Pharmacol, 2007,
559:227-35.
Fernandes ES, Medeiros R, Campos MM, Calixto JB. PAF-induced kinin B1 receptor in vivo
up-regulation: involvement of distinct kinase pathways. Inflammation Research, 2007, 56:
488-491.
Rodrigues GB, Passos GF, Di Giunta G, Figueiredo CP, Rodrigues EB, Grumman A Jr,
Medeiros R, Calixto JB. Preventive and therapeutic anti-inflammatory effects of systemic
and topical thalidomide on endotoxin-induced uveitis in rats. Exp Eye Res, 2007, 84:553-
60.
Prediger RD, Franco JL, Pandolfo P, Medeiros R, Duarte FS, Di Giunta G, Figueiredo CP,
Farina M, Calixto JB, Takahashi RN, Dafre AL. Differential susceptibility following beta-
amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice: Evidence for a
dissociation between cognitive deficits and the glutathione system response. Behav Brain
Res, 2007, 177:205-13.
El Sayah M, Medeiros R, Fernandes ES, Campos MM, Calixto JB. Mechanisms underlying
lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris sphincter in
vitro. Mol Pharmacol, 2006, 69:1701-8.
Prediger RD, Batista L, Medeiros R, Pandolfo P, Florio J, Takahashi R. The risk is in the air:
Intranasal administration of MPTP to rats reproducing clinical features of Parkinson’s
disease. Exp Neurol. 2006, 202:391-403.
Quintão NL, Medeiros R, Santos AR, Campos MM, Calixto JB. The effects of diacerhein on
mechanical allodynia in inflammatory and neuropathic models of nociception in mice.
Anesth Analg, 2005, 101:1763-9.
Ferreira J, Trichês KM, Medeiros R, Calixto JB. Mechanisms involved in the nociception
produced by peripheral protein kinase c activation in mice. Pain, 2005, 117:171-81.
Schlemper V, Medeiros R, Ferreira J, Campos MM, Calixto JB. Mechanisms underlying the
relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in
vitro. Br J Pharmacol, 2005, 145:740-50.
Calixto JB, Medeiros R, Fernandes ES, Ferreira J, Cabrini DA, Campos MM. Kinin B1
receptors: key G-protein-coupled receptors and their role in inflammatory and painful
processes. Br J Pharmacol, 2004, 143:803-18.
Medeiros R, Cabrini DA, Ferreira J, Fernandes ES, Mori MA, Pesquero JB, Bader M, Avellar
MC, Campos MM, Calixto JB. Bradykinin B1 receptor expression induced by tissue damage
in the rat portal vein: a critical role for mitogen-activated protein kinase and nuclear
factor-kappaB signaling pathways. Circ Res. 2004, 94:1375-82.
Medeiros R, Cabrini DA, Calixto JB. The "in vivo" and "ex vivo" roles of cylcooxygenase-2,
nuclear factor-kappaB and protein kinases pathways in the up-regulation of B1 receptor-
mediated contraction of the rabbit aorta. Regul Pept, 2001, 97:121-30.
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