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Alzheimer's Disease Research
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Passos GF, Figueiredo CP, Prediger RD, Silva KA, Siqueira JM, Duarte FS, Leal PC,
Medeiros R, Calixto JB. Involvement of phosphoinositide 3-kinase gamma in the neuro-
inflammatory response and cognitive impairments induced by beta-amyloid 1-40
peptide in mice. Brain Behav Immun. 2009, doi:10.1016/j.bbi.2009.12.003.
Passos GF, Figueiredo CP, Prediger RD, Pandolfo P, Duarte FS, Medeiros R, Calixto
JB. Role of the Macrophage Inflammatory Protein-1α/CC Chemokine Receptor 5
Signaling Pathway in the Neuroinflammatory Response and Cognitive Deficits Induced
by β-Amyloid Peptide. Am J Pathol. 2009 Oct;175(4):1586-97.
Prediger RD, Rial D, Medeiros R, Figueiredo CP, Doty RL, Takahashi RN. Risk is in the
air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of
Parkinson's disease. Ann N Y Acad Sci. 2009, 1170:629-36.
Medeiros R, Figueiredo CP, Passos GF, Calixto JB. Reduced skin inflammatory
response in mice lacking inducible nitric oxide synthase. Biochem Pharmacol. 2009, 78
(4):390-5.
Marotta DM, Costa R, Motta EM, Fernandes ES, Medeiros R, Quintão NL, Campos MM,
Calixto JB. Mechanisms underlying the nociceptive responses induced by platelet-
activating factor (PAF) in the rat paw. Biochem Pharmacol. 2009, 77(7):1223-35.
Medeiros R, Rodrigues GB, Figueiredo CP, Rodrigues EB, Grumman A Jr, Menezes-de-
Lima O Jr, Passos GF, Calixto JB. Molecular mechanisms of topical anti-inflammatory
effects of lipoxin A(4) in endotoxin-induced uveitis. Mol Pharmacol, 2008, 74:154-61.
Quintão NL, Passos GF, Medeiros R, Paszcuk AF, Motta FL, Pesquero JB, Campos MM,
Calixto JB. Neuropathic pain-like behavior after brachial plexus avulsion in mice: the
relevance of kinin B1 and B2 receptors. J Neurosci, 2008, 28:2856-63.
Prediger RD, Medeiros R, Pandolfo P, Duarte FS, Passos GF, Pesquero JB, Campos
MM, Calixto JB, Takahashi RN. Genetic deletion or antagonism of kinin B(1) and B(2)
receptors improves cognitive deficits in a mouse model of Alzheimer's disease.
Neuroscience, 2008, 151:631-43.
Ferreira J, Trichês KM, Medeiros R, Cabrini DA, Mori MA, Pesquero JB, Bader M,
Calixto JB. The role of kinin B1 receptors in the nociception produced by peripheral
protein kinase C activation in mice. Neuropharmacology, 2008, 54:597-604.
Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM,
Pianowski LF, Calixto JB. Anti-inflammatory effects of compounds alpha-humulene
and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J
Pharmacol, 2007, 569:228-36.
Medeiros R, Prediger RD, Passos GF, Pandolfo P, Duarte FS, Franco JL, Dafre AL, Di
Giunta G, Figueiredo CP, Takahashi RN, Campos MM, Calixto JB. Connecting TNF-
alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's
disease: relevance for the behavioral and synaptic deficits induced by amyloid beta
protein. J Neurosci, 2007, 27:5394-404.
Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM,
Calixto JB. Effect of two active compounds obtained from the essential oil of Cordia
verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J
Pharmacol, 2007, 151:618-27.
Medeiros R, Otuki MF, Avellar MC, Calixto JB. Mechanisms underlying the inhibitory
actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation
induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Eur J Pharmacol,
2007, 559:227-35.
Fernandes ES, Medeiros R, Campos MM, Calixto JB. PAF-induced kinin B1 receptor in
vivo up-regulation: involvement of distinct kinase pathways. Inflammation Research,
2007, 56:488-491.
Rodrigues GB, Passos GF, Di Giunta G, Figueiredo CP, Rodrigues EB, Grumman A Jr,
Medeiros R, Calixto JB. Preventive and therapeutic anti-inflammatory effects of
systemic and topical thalidomide on endotoxin-induced uveitis in rats. Exp Eye Res,
2007, 84:553-60.
Prediger RD, Franco JL, Pandolfo P, Medeiros R, Duarte FS, Di Giunta G, Figueiredo
CP, Farina M, Calixto JB, Takahashi RN, Dafre AL. Differential susceptibility following
beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice:
Evidence for a dissociation between cognitive deficits and the glutathione system
response. Behav Brain Res, 2007, 177:205-13.
El Sayah M, Medeiros R, Fernandes ES, Campos MM, Calixto JB. Mechanisms
underlying lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris
sphincter in vitro. Mol Pharmacol, 2006, 69:1701-8.
Prediger RD, Batista L, Medeiros R, Pandolfo P, Florio J, Takahashi R. The risk is in the
air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson’
s disease. Exp Neurol. 2006, 202:391-403.
Quintão NL, Medeiros R, Santos AR, Campos MM, Calixto JB. The effects of diacerhein
on mechanical allodynia in inflammatory and neuropathic models of nociception in
mice. Anesth Analg, 2005, 101:1763-9.
Ferreira J, Trichês KM, Medeiros R, Calixto JB. Mechanisms involved in the
nociception produced by peripheral protein kinase c activation in mice. Pain, 2005, 117:
171-81.
Schlemper V, Medeiros R, Ferreira J, Campos MM, Calixto JB. Mechanisms underlying
the relaxation response induced by bradykinin in the epithelium-intact guinea-pig
trachea in vitro. Br J Pharmacol, 2005, 145:740-50.
Calixto JB, Medeiros R, Fernandes ES, Ferreira J, Cabrini DA, Campos MM. Kinin B1
receptors: key G-protein-coupled receptors and their role in inflammatory and painful
processes. Br J Pharmacol, 2004, 143:803-18.
Medeiros R, Cabrini DA, Ferreira J, Fernandes ES, Mori MA, Pesquero JB, Bader M,
Avellar MC, Campos MM, Calixto JB. Bradykinin B1 receptor expression induced by
tissue damage in the rat portal vein: a critical role for mitogen-activated protein kinase
and nuclear factor-kappaB signaling pathways. Circ Res. 2004, 94:1375-82.
Medeiros R, Cabrini DA, Calixto JB. The "in vivo" and "ex vivo" roles of
cylcooxygenase-2, nuclear factor-kappaB and protein kinases pathways in the up-
regulation of B1 receptor-mediated contraction of the rabbit aorta. Regul Pept, 2001, 97:
121-30.
Medeiros R, Calixto JB. Involvement of phosphoinositide 3-kinase gamma in the neuro-
inflammatory response and cognitive impairments induced by beta-amyloid 1-40
peptide in mice. Brain Behav Immun. 2009, doi:10.1016/j.bbi.2009.12.003.
Passos GF, Figueiredo CP, Prediger RD, Pandolfo P, Duarte FS, Medeiros R, Calixto
JB. Role of the Macrophage Inflammatory Protein-1α/CC Chemokine Receptor 5
Signaling Pathway in the Neuroinflammatory Response and Cognitive Deficits Induced
by β-Amyloid Peptide. Am J Pathol. 2009 Oct;175(4):1586-97.
Prediger RD, Rial D, Medeiros R, Figueiredo CP, Doty RL, Takahashi RN. Risk is in the
air: an intranasal MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) rat model of
Parkinson's disease. Ann N Y Acad Sci. 2009, 1170:629-36.
Medeiros R, Figueiredo CP, Passos GF, Calixto JB. Reduced skin inflammatory
response in mice lacking inducible nitric oxide synthase. Biochem Pharmacol. 2009, 78
(4):390-5.
Marotta DM, Costa R, Motta EM, Fernandes ES, Medeiros R, Quintão NL, Campos MM,
Calixto JB. Mechanisms underlying the nociceptive responses induced by platelet-
activating factor (PAF) in the rat paw. Biochem Pharmacol. 2009, 77(7):1223-35.
Medeiros R, Rodrigues GB, Figueiredo CP, Rodrigues EB, Grumman A Jr, Menezes-de-
Lima O Jr, Passos GF, Calixto JB. Molecular mechanisms of topical anti-inflammatory
effects of lipoxin A(4) in endotoxin-induced uveitis. Mol Pharmacol, 2008, 74:154-61.
Quintão NL, Passos GF, Medeiros R, Paszcuk AF, Motta FL, Pesquero JB, Campos MM,
Calixto JB. Neuropathic pain-like behavior after brachial plexus avulsion in mice: the
relevance of kinin B1 and B2 receptors. J Neurosci, 2008, 28:2856-63.
Prediger RD, Medeiros R, Pandolfo P, Duarte FS, Passos GF, Pesquero JB, Campos
MM, Calixto JB, Takahashi RN. Genetic deletion or antagonism of kinin B(1) and B(2)
receptors improves cognitive deficits in a mouse model of Alzheimer's disease.
Neuroscience, 2008, 151:631-43.
Ferreira J, Trichês KM, Medeiros R, Cabrini DA, Mori MA, Pesquero JB, Bader M,
Calixto JB. The role of kinin B1 receptors in the nociception produced by peripheral
protein kinase C activation in mice. Neuropharmacology, 2008, 54:597-604.
Fernandes ES, Passos GF, Medeiros R, da Cunha FM, Ferreira J, Campos MM,
Pianowski LF, Calixto JB. Anti-inflammatory effects of compounds alpha-humulene
and (-)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J
Pharmacol, 2007, 569:228-36.
Medeiros R, Prediger RD, Passos GF, Pandolfo P, Duarte FS, Franco JL, Dafre AL, Di
Giunta G, Figueiredo CP, Takahashi RN, Campos MM, Calixto JB. Connecting TNF-
alpha signaling pathways to iNOS expression in a mouse model of Alzheimer's
disease: relevance for the behavioral and synaptic deficits induced by amyloid beta
protein. J Neurosci, 2007, 27:5394-404.
Medeiros R, Passos GF, Vitor CE, Koepp J, Mazzuco TL, Pianowski LF, Campos MM,
Calixto JB. Effect of two active compounds obtained from the essential oil of Cordia
verbenacea on the acute inflammatory responses elicited by LPS in the rat paw. Br J
Pharmacol, 2007, 151:618-27.
Medeiros R, Otuki MF, Avellar MC, Calixto JB. Mechanisms underlying the inhibitory
actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation
induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Eur J Pharmacol,
2007, 559:227-35.
Fernandes ES, Medeiros R, Campos MM, Calixto JB. PAF-induced kinin B1 receptor in
vivo up-regulation: involvement of distinct kinase pathways. Inflammation Research,
2007, 56:488-491.
Rodrigues GB, Passos GF, Di Giunta G, Figueiredo CP, Rodrigues EB, Grumman A Jr,
Medeiros R, Calixto JB. Preventive and therapeutic anti-inflammatory effects of
systemic and topical thalidomide on endotoxin-induced uveitis in rats. Exp Eye Res,
2007, 84:553-60.
Prediger RD, Franco JL, Pandolfo P, Medeiros R, Duarte FS, Di Giunta G, Figueiredo
CP, Farina M, Calixto JB, Takahashi RN, Dafre AL. Differential susceptibility following
beta-amyloid peptide-(1-40) administration in C57BL/6 and Swiss albino mice:
Evidence for a dissociation between cognitive deficits and the glutathione system
response. Behav Brain Res, 2007, 177:205-13.
El Sayah M, Medeiros R, Fernandes ES, Campos MM, Calixto JB. Mechanisms
underlying lipopolysaccharide-induced kinin B1 receptor up-regulation in the pig iris
sphincter in vitro. Mol Pharmacol, 2006, 69:1701-8.
Prediger RD, Batista L, Medeiros R, Pandolfo P, Florio J, Takahashi R. The risk is in the
air: Intranasal administration of MPTP to rats reproducing clinical features of Parkinson’
s disease. Exp Neurol. 2006, 202:391-403.
Quintão NL, Medeiros R, Santos AR, Campos MM, Calixto JB. The effects of diacerhein
on mechanical allodynia in inflammatory and neuropathic models of nociception in
mice. Anesth Analg, 2005, 101:1763-9.
Ferreira J, Trichês KM, Medeiros R, Calixto JB. Mechanisms involved in the
nociception produced by peripheral protein kinase c activation in mice. Pain, 2005, 117:
171-81.
Schlemper V, Medeiros R, Ferreira J, Campos MM, Calixto JB. Mechanisms underlying
the relaxation response induced by bradykinin in the epithelium-intact guinea-pig
trachea in vitro. Br J Pharmacol, 2005, 145:740-50.
Calixto JB, Medeiros R, Fernandes ES, Ferreira J, Cabrini DA, Campos MM. Kinin B1
receptors: key G-protein-coupled receptors and their role in inflammatory and painful
processes. Br J Pharmacol, 2004, 143:803-18.
Medeiros R, Cabrini DA, Ferreira J, Fernandes ES, Mori MA, Pesquero JB, Bader M,
Avellar MC, Campos MM, Calixto JB. Bradykinin B1 receptor expression induced by
tissue damage in the rat portal vein: a critical role for mitogen-activated protein kinase
and nuclear factor-kappaB signaling pathways. Circ Res. 2004, 94:1375-82.
Medeiros R, Cabrini DA, Calixto JB. The "in vivo" and "ex vivo" roles of
cylcooxygenase-2, nuclear factor-kappaB and protein kinases pathways in the up-
regulation of B1 receptor-mediated contraction of the rabbit aorta. Regul Pept, 2001, 97:
121-30.
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